Ibuprofen Liver Damage

Acetaminophen Hazards

Acetaminophen leads to 3 times as numerous instances of poorly liver failing because other medicines mixed, and it is the most typical reason for severe poorly liver failing in the usa, sales with regard to 39% of instances. Although it happens via overdosing, actually suggested dosages particularly coupled with actually a small amount of alcoholic beverages, possess triggered permanent poorly liver failing.
Acetaminophen is actually digested within the poorly liver, producing a by-product, N-acetyl-p-benzoquinone imine (NAPQI), that may harm poorly liver tissue, however is usually changed into the safe material through a good antioxidant glutathione. Nevertheless, big dosages of acetaminophen overwhelms your body's way to obtain glutathione, leading to damage of the poorly liver tissue.
Those who have the greatest danger with regard to Acetaminophen associated kidney failing consist of: large consumers (three or even more beverages for each day), seniors males, and additionally individuals along with pre-existing poorly liver and kidney harm. Within babies and additionally young children, research possess pointed out how the poisonous dosage is actually under two times the suggested dosage.
Research released through the Diary of the United states Healthcare Organization within 2006 indicates difficulties actually within wholesome individuals getting the discomfort reliever because aimed. Wholesome grown ups getting optimum dosages of Tylenol for 2 days experienced irregular poorly liver check outcomes. Doctor. Neil Kaplowitz of the College of The southern area of Ca, co-author of the research, stated, "I might desire the general public to not surpass 4 gr each day. This can be a medication which has a instead thin security eye-port... inch
Based on an initial research combining acetaminophen and additionally coffee could cause poorly liver harm, particularly within large coffee consumers. Scientists learned that coffee may multiple the quantity of, N-acetyl-p-benzoquinone imine (NAPQI), the harmful through item that damages poorly liver tissue. This particular response may also be brought on by big dosages of painkillers which mix coffee and additionally acetaminophen (e. grams., Anacin, Excedrin & Midol). These items can be used to deal with migraine headaches and additionally menstrual soreness. Doctor. Sid Nelson, the teacher of therapeutic biochemistry in the College of Wa stated, "Caffeine may connect to a good enzyme that may type the poisonous metabolite of acetaminophen so it boosts the development of this poisonous metabolite".
Signs and symptoms through a good overdose of acetaminophen usually seem following twenty four hours, and in some instances as much as forty eight several hours; nevertheless, obtaining instant remedy just before signs and symptoms happening, may significantly enhance the end result. The antidote in order to acetaminophen overdose, N-acetylcysteine (NAC), is actually best whenever used inside eight-hours of the overdose. Because of the postponed signs and symptoms and also the need for instant remedy, overdoses of acetaminophen destroy regarding 12% of these that look for remedy. Standard signs and symptoms vary from nausea or vomiting and additionally malaise in order to severe top stomach discomfort around the poorly liver.
Tylenol is just one amongst numerous well-liked medicines that contains acetaminophen, however couple of customers recognize that it's found in countless additional discomfort relievers and additionally chilly treatments, which mixed utilization includes a cumulative impact. 15 % of unintentional overdoses include the simultaneous make use of in excess of 1 item that contains acetaminophen. Items through typical manufacturers consist of acetaminophen: Excedrin, Midol, Theraflu, Alka-Seltzer and additionally NyQuil, in addition to doctor prescribed drugs for example Vicodin and additionally Percocet. Following a suggested doses for every, however in mixture may much surpass secure limitations with regard to acetaminophen consumption. The producers of Tylenol suggest, "You shouldn't consider several items which contain acetaminophen simultaneously. inch.

Frequently Asked Questions

  1. QUESTION:
    Can Ibuprofen cause liver damage?

    • ANSWER:
      Take it from this nurse. Ibuprofen taken as only needed as it states on the bottle is safe but if you take to much of it as well as any other medications you will not only harm your liver but also your kidneys and other organs. Take all medication only as recommended on the bottle.

  2. QUESTION:
    will ibuprofen cause liver or kidney damage? I took 800 milligram's at 5 pm , it's now 8 pm and I took another?

    • ANSWER:
      800 mg should be every 8 hours. Don't take anymore tonight so there will be a decent amount of time before you take anymore. One single dose too close together will not cause liver or kidney damage - it is when you continue to do this over a period of time that it becomes dangerous for your body.

  3. QUESTION:
    If I took 3 Ibuprofen in about 6 hours, will that cause any damage to my stomach or liver?
    I had a massive headache today.. so I took an Ibuprofen at 8:30AM, then another one at 9AM. That helped it go away.. but then it came back so I took another one at 2:30PM.

    • ANSWER:
      youl be fine just keep drinking fluids that a number 1 cause of head aches dehydration hope this helps

  4. QUESTION:
    Can anyone tell me the signs of liver damage due to taking presciption painkillers for several years ?
    Also , which is worse on your liver high doses of acetiminophen or ibuprofen ?

    • ANSWER:
      Yes I can, signs of liver damage from anything are: fatigue, acidy stomach, feeling run down, dark yellow urine, dark brown urine, white chalky poo, swollen stomach, tenderness just under the ribcage on the right side, take your right hand and lay it on your ribcage line the knuckles at the end of the ribcage and press in and up on your right side, if that hurts, aches or feels bad in any way you have swelling in your liver, indicating damage. Itchy skin, that is not relieved by scratching, head aches, feeling like you just cant get your normal level of energy, over emotional (toxins in your system can make you feel poisonous and nasty, making your mood nasty and hostile). The damage can heal itself if it is not too far gone but you have to stop taking the aspirin, ibuprofin and pain pills for at least 90 days and put brewers yeast in your cereal in the morning, take vitamins, stop eating anything with oil, fat salt or sugar in it, and drink lots of water to rinse your system, get a ton of rest, your body heals faster while you are sleeping. Take support vitamins but be careful what you take, or how much you take because too many of some vitamins can damage the liver and kidneys too. One other way to check is to have a friend or family member go outside with you in the sun shine and you look up down and left too right and ask them to see if there is any yellow in the corners or a yellow tint to the whites of your eyes, if yes? you better take the next step and get a blood test called S.M.A.C, it shows all of your liver enzymes, salts, sugars and fats, a great test and a great way to monitor damage while healing also. Good luck...

  5. QUESTION:
    How do I ask for a liver damage test?
    Don't ask me why but I have overdosed a lot of times on tylenol and also ibuprofen...probably 5-6 times over the last 3 years. Please save the comments about I need help. But I just want to know how I can ask my doc for a liver damage test.... what's it called , etc.... thanks

    • ANSWER:
      liver function test or hepatic function test... it would also be wise to disclose your history of overdoses to the doctor as well... could determine how they treat your liver issues.

  6. QUESTION:
    permanent liver damage from motrin pills?
    for a female who is of average weight, 16.
    and had hepatitus b when younger.
    If she took a whole bottle of ibuprofen pills , how much damage or permanent liver damage would it be. how bad?
    HYPOTHETICAL QUESTION-calm yourselves

    • ANSWER:
      Motrin (ibuprofen) can cause renal (kidney) damage in larger doses taken over a period of time, A one time overdose such as this would cause gastric upset and potential stomach ulceration, but it would be unlikely to cause any renal damage from the single dose.

      Ibuprofen does not affect the liver. Acetaminophen is toxic to your liver in longer term doses exceeding 4,000milligrams per day, and can be toxic from a single large dose as well.

      Acetylcysteine is used to reverse the toxicity of acetaminophen, and is fairly effective if used in time.

      Chronic overdoses from Acetaminophen are responsible for as many as 230 deaths from liver failure in America each year.

  7. QUESTION:
    How long can you take ibuprofen until you really start damaging your liver and kidney?
    I have chronic foot pain and I am going through the worst right now. It has been 2 and a half weeks and it's not getting much better. I've been taking generic brand ibuprofen this whole time. Sometimes I take 800 mgs a day, sometimes up to 2000 mgs. I want to stop and take a break at least for one day but the pain gets so bad at night, I take 800 mgs again. I don't want to have permanent liver damage and I only have one kidney.

    Is it safe to keep taking for a little while longer or should I just stop cold turkey? If so, what's an alternative pain medication that doesn't damage the liver and kidneys? What can I take for the pain?

    • ANSWER:
      Most liver and kidney patients are told not
      to take any medication that isn't approved
      of or prescribed by their doctors.

      The reason for this, is because most
      all medications go through the liver first,
      to be broken down, before going to the rest
      of the body. Also, because the certain drugs
      can become toxic to the liver or kidneys very
      easily and cause cell damage.
      All medications includes over the counter meds,
      herbs, vitamins, minerals, supplements, etc.

      Only the doctor can tell if there is a problem
      with an organ because of drugs. He does blood
      testing and in this case, he would look at the
      Creatinine level and Bun (blood urea nitrogen)
      level to see how well the kidney is able to
      do the functions needed to keep the body well.
      Without the results of this test, you don't know
      whether you are harming your kidney or not.

      I would contact your doctor about the pain you are
      having in your foot. There must be some reason for
      this: gout, arthritis, diabetes or others. If he determines
      you should be on medications...he will weigh the pros
      and cons of the medications he can use on you that
      won't harm the kidney. Considering you only have one,
      really makes this very necessary.

      To tell you what drug you could take would be just
      a guess and that guess could cost you the only kidney
      you have left.

      Hope this information is of some help to you.

  8. QUESTION:
    I have been taking 200 mg ibuprofen once a night for the last 3 months. Is this potentially dangerous?
    I had an extensive hernia repair surgery late May, and to deal with the pain and swelling, I had/have been taking 200 mg of ibuprofen once a night for the last 2 months, on top of the Hydro-ibuprofen combination the doctor told me to take the first month . I don't drink alcohol, but I have Crohn's, and I take 100 mg 6-MP (another probable Hepatotoxic) a day. My liver results have always come back fine, but that was all pre-op. Do I need to worry about this?? Should I go to the Crohn's doctor and request more blood work, or just wait until the next appointment in November? If the combination of 6-mp and ibuprofen caused some kind of liver damage, what symptoms would I look for? Thank you for your time.

    • ANSWER:
      200 mg ibuprofen is not a big dose of a non-steroidal anti-inflammatory. It should not interact with the mercaptopurine, as the main toxicity of the NSAID's is on the stomach lining, or potentially (and this is a LONG shot!) the kidney. In excessive doses in a person who may be dehydrated, NSAID's may cause kidney toxicity, but at this dosage, as long as you are well hydrated, does not present any danger to your kidneys.
      If you did have liver damage from any of the drugs you are taking, you might experience loss of appetite, discomfort in the right upper quadrant of the abdomen, dark urine, or yellowing of the whites of your eyes (jaundice).
      Unless your own physician tells you otherwise, I don't think that 200 milligrams of ibuprofen is dangerous to your health..
      Good luck to you!

  9. QUESTION:
    How long does it take for ibuprofen to start causing damage?
    ok so if u overdose by say double the stated dose of ibuprofen a day when will affects on your liver, or problems with ur stomach start to show.
    Also any info u have about other amounts of an ibuprofen overdose i would be greatful

    • ANSWER:
      I'll share my experience with Ibuprofen. I Would like it better if it was more effective against pain, but it generally works as described. Lasts about 3 to 4 hours. Side effects: none. I purchase Ibuprofen through reputable http://www.lipmanpharmacy.com/ they've been very reliable so far. Check this FDA link about Ibuprofen http://google2.fda.gov/search?client=FDAgov&site=FDAgov-Recalls-Safety|FDAgov-Consumers|FDAgov-WarningLetters-ICECI|FDAgov-ImportAlerts-Industry|FDAgov-MedWatch-Safety|FDAgov-Section-Drugs&output=xml_no_dtd&proxystylesheet=FDAgov&ie=UTF-8&oe=UTF-8&as_q=ibuprofen&num=20&btnG=Search&as_epq=&as_oq=&as_eq=&restrictBox=FDAgov-Recalls-Safety&restrictBox=FDAgov-Consumers&restrictBox=Medwatch&restrictBox=FDAgov-WarningLetters-ICECI&restrictBox=FDAgov-ImportAlerts-Industry&restrictBox=FDAgov-Section-Drugs&lr=&as_ft=i&as_filetype=&as_occt=any&as_dt=i&as_sitesearch=&sort=date
      Hope i helped.

  10. QUESTION:
    I am 68 yrs old I take one ibuprofen a day for aches and pains,will this do any damage to my liver?

    I do not take any other medications. I do take vitamins though and have done for years. My blood pressure is 98/68. I also take glucosamine /condroiton for the joints its helps greatly. The ibuprofen just takes the edge off and I can move around with ease of motion.

    • ANSWER:
      Unless you already have liver disease I doubt very much that this low dose would ever harm your liver. However, a simple blood test will tell you for sure.

  11. QUESTION:
    What are signs of liver damage?
    Yes, I already know that signs include yellowing of skin and eyes, and nausea but i dont have any of that.

    august 2009- i took 14 extra strength tylenol
    plus 9 advil PM pills

    after that, went 2 ER and hospital for a week.

    then i was ok, i did not pass out, felt fine except extreme dry throat, mouth, shaking, heart beating faster.

    i lived...now it's now november.

    november 3rd i had the worst cramps ever and was in so much pain i had to take 2 extra strength tylenol.

    they had no absoulte effect and i was in more worse pain.
    and after that everything felt diff. my liver/upper stomach in the middle feels absolutely bloated and tight and kinda hard. it feels feel uncomfortable and just really tight and big! i swear and i already had digestion problems ever since i overdosed once but i was fine and ate fine...but

    after taking those 2 more tylenol,
    my body like felt swollen- my liver feels so tight and totally bloated

    help. do you think it has to do with the ibuprofen and tylenol?
    could i have liver damage and not know it?
    i do get cuts easily like if i scrape my hand accidentally it automatically leaves a red scar.

    my liver/upper stomach feels so tight and bloated.

    help me

    • ANSWER:
      I am not a doctor. I do have end stage liver disease from alcohol. My liver feels like a dirty brick was stuffed in to it, jagged edges of old mortar and all. I bled like crazy. Every bowel movement, one half cup of blood. Nose bleeds that bled so hard that as I cleaned up the mess, it just spread and spread, and I gave up and looked like someone had stabbed me. Shirt was soaked with blood, and pants too.Spleen is enlarged from high blood pressure in the liver, blood is backing up in to spleen and else where. I feel foggy, like confused and angry all the time. I have encephalopathy--Tired, so so tired. Headaches from dilated blood vessles. I have hepatopulmonary syndrome, from unfiltered nitric oxide. Cant breathe. Sleep with oxygen. You could have liver damage and not know it. NONE of my doctors did untill biopsy results. My liver fooled everyone. All that tylenol should have killed you and I would not be at all suprised if you have ESLD. I hope and pray you do not!

  12. QUESTION:
    Possible liver damage?
    So, just about I'd say about 10 months ago, I had a severe overdosing issue. I guess you could say I was depressed, I still think I am but I control myself, and to drown out mental pain I would take a hell's worth of ibuprofen pills. They were extra strength pills, so about 14 would have the exact same amount of aspirin as about 28. I would take from about 9 to 16 every few weeks. It was highly painful, and the type I took (Bayer: Back and Body Extra strength) for some reason, was different from the others and I didn't feel the need to throw them up. After about the 4th time of taking the pills, I had gone to the bathroom that same day, and my urine was absolutely clear and my bladder was much more full than usual, even though I had absolutely no water with the pills. My stomach hurt even more than usual. I stopped on the ibuprofen pills, afraid of permanent damage. I think I might've been too late. Now, once in a while, I lose much color though I haven't taken any pills. There are slight, and I mean very slight, but constant daily leakages that I can't control. I tried to ignore it, but now I'm a little worried. I can't go to a doctor about this for reasons I'd rather not go through. Could this be liver damage?

    • ANSWER:

  13. QUESTION:
    Liver damage????
    I have pain in my legs. The doc said it is from my cholesterol med. He gave me some med., but I can't take it because I work and it makes me sleepy. I have been taking 1/2 of a motrin 800 twice aday and fill in with 3 over the counter motrins. I have been doing this for about 1 mo. now and it works. Am I damaging my liver with this amount of ibuprofen (motrin)

    • ANSWER:
      u need to get in touch with doctor richard l becker he can help! he is in rock wall tx!

  14. QUESTION:
    Can i take beer with ibuprofen?
    i just took 1200 mg of ibuprofen with a Budweiser... am i at risk for liver damage or something else? some one told me that it's only Tylenol that you can't drink with.

    • ANSWER:
      You are fine. If you did this EVERY day it would be another matter. Liver damage occurs over a period of time, not in one time of Bud and meds.

  15. QUESTION:
    liver damage signs......?
    what are the symptoms and signs for liver damage in chronic usage of medicines such as tylenol and ibuprofen? how long usually would you need to use these to irreversibly damage your liver or other organs?

    • ANSWER:
      major indicator would be what is called jaundice. google it or go to web md for symptoms. mainly skin, whites of eyes, nails, etc will have a mild yellowing appearance. it's something to look into.

      unless you have some pre-existing conditions and you aren't abusing usage (taking 8 vs 2 pills, or heavy drinking with high dosage), this won't happen. The active ingredient in tylenol is acetomidophine, which can cause liver damage in high amounts. Ibuprofen is the active ingredient in advil, which had a much lower risk factor to the liver but gives less pain relief. if you are that worried, adopt advil vs tylenol if you have no preference. or ask your dr.

  16. QUESTION:
    Which is safer Ibuprofen or Tylenol?
    Which is safer Ibuprofen or Tylenol?
    Tylenol causes liver damage and Ibuprofen cause stomach bleeding but which is safest? Please list Sources (i.e. website with articles on this topic) if known. Are there other over the counter pain killers that are safer? Also what would be a good pain killer for someone that consumes more than 3 alcoholic drinks a day since the Tylenol and Ibuprofen both say not to take if one consumes more than 3 or more alcoholic drinks a day

    Additional Details

    i'm needing to take a pain reliever for pms cramps and im alot a binge drinker..about once a week or so...
    I DONT TAKE THE BOOZE WITH THE PILLS I TRY NOT TO DRINK DURING AND RIGHT BEFORE THAT TIME OF THE MONTH

    • ANSWER:
      Tylenol and Ibuprofen are both very safe. If you're taking them for PMS, ibuprofen is better equipped to handle your type of pain since it is an NSAID drug. It helps reduce inflammation caused by PMS, therefore helping the pain you are feeling. As for drinking, I don't recommend you drink with the pills, I would take the pills at least 3 hours before your first drink to allow them to break down and move through the stomach before you get all jacked up.

  17. QUESTION:
    do you think i have liver damage?
    so my friend and i shared a sprite but he had added 2ounces of ibuprofen cough syrup into da sprite do you think dat cold of caused any liver damage

    • ANSWER:

  18. QUESTION:
    overdose? liver damage?
    first of all its my friend NOT ME! anyways my friend when she was 11 in feb. toke over 100 ibuprofen pills, i dont know why. she turned 12 on march 18th, all that happened was vomiting the night of the overdose, she went back to school perfect. its now couple months after, in gym she was a good runner, shes the only 6th grader on the track team, & now she cant even keep up, she weighs about 120 when the overdose happened but shes skinny & VERY tall. she has no energy, & is always tired, she said it was a suicide attempt, her parents dont know, no doctors dont know, & only i do she said shes scared she might have liver damage, or kidney, if so what are some signs? & if she did, even though schools almost over would she miss school if she went too a hospital, she said if she has damage she will tell her parents, shes really scared & she said the research is confusing, she has been confused alot, awkwardly she said her grades improved so idk about that, just please answer about sgins & did she even overdose? help, both her & i are scared & shes next to me, but her shes too busy texting
    please answer, what are some SIGNS & what happens with liver damage?
    also she made this account but didnt want to type because she broke into tears she doesnt know & will get mad if she find out but her name is Maddie Burkhardt easier if you type in (maddielizrocks@aol.com) you can look her up on facebook & please try too talk too her, she wants to tell her parents but doesnt know how

    • ANSWER:
      You need to tell an adult. She needs to be treated by a doctor. She vomited enough of the ibuprofen that she didn't get a fatal dose, but she needs to be treated for potential damage.

  19. QUESTION:
    Do I have liver damage?
    Don't judge me on my stupidity.

    On Tuesday I took 12 ibuprofen, Thursday 8 and on Friday 6 with 2 solpadol (paracetamol + codeine) tablets. All the pills, on the day, were taken within about 5 minutes. Don't ask me why, but I am an idiot.

    Since Thursday/Friday I haven't been able to eat properly, every time I try to eat a meal I feel sick and have diarrhoea afterwards, and I heard this is an early sign of acute liver damage. However, since I haven't been to the loo properly in about a week could this just be a coincidence, or do you think I should get it checked out?

    Thanks.

    • ANSWER:
      There are about 1000 different things that could cause nausea and then diarrhea. Never saw this listed as a sign of acute liver failure. Sounds more like a stomach problem. If you are worried about your liver, go to the doctor and get some liver function blood work done.

  20. QUESTION:
    If I only drink one day per week, but get drunk that one day, do I still risk long term liver damage?
    I have 6 alcohol-free days a week, but Friday night is my "going out" night and I usually pay for it on Saturday AM. I do not take any prescription medications and almost never take OTC meds like acetominaphen/ibuprofen. I workout every day, have normal blood pressure & cholesterol and have a very healthy diet otherwise. I usually only drink distilled water or tea, sometimes coffee, never drink soda. I take several vitamin supplements, lots' of Omega-3s, eat lots of fruits & veggies, eat very little red meat, mostly fish and organically raised chicken. But I like to party on Fridays and have been doing this for years. What is my risk of long-term damage to my liver?

    • ANSWER:
      If you have 5 or more drinks on that one day, you're engaging in binge drinking behavior.

      It does risk damage to your liver, but it's not really possible to accurately quantify the damage. It's certainly healthier than heavy drinking every day, but it's also more harmful than having one or two drinks a day.

      Any health practitioner would advise you to cut back, but you're relatively low risk in the grand scheme of alcohol related disease.

  21. QUESTION:
    How many Ibuprofen/Tylenol pills does it take to harm your body?
    I've been having frequent headaches for years and most recently pains from braces, and I've been taking alot of pills. How many does it take to give you liver damage? Only serious answers. And I'm not trying to kill myself btw

    • ANSWER:
      If you take more than 8 Tylenol tablets in a day then you risk liver damage.

      The site does not mention dangers from long term use.

      I could not find out anything relating Ibuprofen to liver damage.

  22. QUESTION:
    Is it unhealthy to take ibuprofen (advil) too frequently?
    I've been taking Advil 200mg ibuprofen capsules almost daily for a little while to deal with annoying headaches. Is this safe to do for extended periods of time or should I find another way to deal?

    Also, would acetaminophen (Tylenol/paracetamol) be a safer choice? I know it carries a risk of severe liver damage in high doses, but does it have fewer side effects associated with long term usage?
    I usually don't take more than one dose in a day, unless pain comes back or is especially bad.

    • ANSWER:
      I know that after taking those drugs for years to aide my period cramps, i delveloped ulcers, which my doctor said was for sure linked to my asprin and ibprofen intake. I was even using the drugs in the right instructions on the back of the bottles! If you look on them, the bottles warn you that the drugs may cause stomach bleeding and other of other side effects.

      And yes the doctor also told me that acetaminophen is a much better choice.

  23. QUESTION:
    What do you do when you can't take aspirin, Ibuprofen or Naproxen for aches and pains.?
    I have terrible reflux for which I take Prilosec. But it doesn't control the bad action after taking aspirin, etc. I take Tylenol now, but am afraid of liver damage. I feel others have this problem too, and would like to know how they are handeling it. Thanks in advance.

    • ANSWER:
      If the aches and pains are a daily thing, please go to your doctor and find out what the problem is. If it's only occasional aches and pains, and you take tylenol a couple of times a week, then there is no harm at all. It's really only a problem if you take maximum doses (or more) every single day and you are not being monitored by your doctor.

  24. QUESTION:
    Alcohol and Ibuprofen?
    I am sick, but my friend is having a party tomorrow. I am planning on getting pretty drunk, but I don't think I can handle a party without ibuprofen, as my symptoms are pretty bad. So
    1 Is there a good chance that it will result in liver damage?
    2 Will the ibuprofen alter my state of intoxication?

    • ANSWER:
      1. Is there a good chance that it will result in liver damage?
      Ibuprofen will do nothing, the alcohol will obviously cause liver damage, dont'chya know?

      2. Will the ibuprofen alter my state of intoxication?
      No.

  25. QUESTION:
    Can Ibuprofen be causing problems with my liver and kidneys?
    I had a blood test recenetly and my doctor told me I have potentially damage to my liver and kidneys. He gave me some prescription tea etc, to try to get the toxins that caused this, out of my body. I have had recurring shoulder pain for 10 years. I have been taking Ibuprofen for that for 10 years. When I told him that he thought immediately that was the problem. But I am afraid it could be something worse causing the problem. I am in good shape and I am never overly fatigued etc. So could it really be the Ibuprofen?

    • ANSWER:
      Rx tea?? Does not sound like a regular medical doctor.

      Ibuprofen, like all the super asprin like NSAIDs tends to cut down on blood flow to the kidneys, and long term use is hard on the kidneys.

      Acetaminophen (the active ingredient in tylenol and many other products) can be hard on the liver. Alcohol use makes it worse.

      Just stop taking any of these pain or fever pills, its going to kill you, if it has not already done so.

  26. QUESTION:
    How much Ibuprofen is safe at once?
    I have a headache, and I want to make sure I don't take too much. The most I have ever taken was 13 of the 200mg tablets. It was an accident the time I did that. So anyways, How much is safe at once? And also, how dangerous is Ibuprofen? How long would it take for serious damage to your liver or somach lining?

    • ANSWER:
      The max dose when used as a prescription is 3200mg a day or 800mg (4 tablets) every 6 hours. That being said this dose is not safe for everyone, it can cause GI ulcers or induce acute renal failure in certain individuals. On top of that if you really are needing to take this much, particularly on a regular basis you need to discuss it with a doctor to make sure it isn't a more serious problem, or something such as a migraine that could be better treated with prescription medications.
      The most you should be taking over the counter is 400mg every 6 hours for no more than a week or so.
      That being said I'll admit I personally do take 600 to 800 on rare occasions when needed, but I know my renal function from lab work I have had done before, and I know all the risk factors for GI bleeding, that isn't something a lay person is really qualified to determine.

      As a side note, how the hell do you take 13 tablets on accident?

  27. QUESTION:
    If you take the maximum dosage of ibuprofen...?
    so like however many pills is the maximum on the bottle and you keep taking them for a long number of days even when you really don't need the ibuprofen for anything... what would happen? liver damage? could it be life threatening?

    • ANSWER:
      Even at lower doses, the main risk from NSAID's is GI bleeding. It has been suggested that GI bleeding from NSAID's may be associated with over 100,000 hospitalizations and over 16,000 deaths in the US annually. That sounds like a huge number, but the 100,000 is less than 2% of people using the drugs, so it's relatively safe.

  28. QUESTION:
    Does overdosing on tylenol for sure cause liver damage?
    I was suicidal last year and had taken more than 60 tylenols at time. I consumed whole bottles at once on several occasions. for about 2-3 days I stayed nauseous but then i got okay. It wasnt just tylenols, i took lots of ibuprofen, Prozacs, hydrochlorothiazides, expired blood pressure pills basically almost every OTC medication I could get my hands on.

    When all of this came out I was taken into emergency and they said everything is A-OK.
    but now i'm getting all these absurd pains in my stomach and head and my heart beat is seldom calm.

    I really don't want to worry my family and friends about it and I especially dont want to remind them of last year. So I don't want to get anyone else involved. i'm hoping it's got nothing to do with the pills i had taken and it's really something else?

    I know it's stupid that I'm asking this question here but I just really want assurance that I dont have to get my parents involved because i've put them through enough already.

    thanks guys.

    • ANSWER:
      It most likely isn't from overdosing, but it could be. And yes, overdosing on tylenol does cause liver damage. A few years back, I did almost the same thing as you but a little worse and now my liver does have damage to it. I wouldn't stress too much, but if the problem persists I suggest you go see a doctor. But, without your parents knowing if you don't want to upset them. I hope this helps, and all goes well. Im sure you'll be fine hun.

  29. QUESTION:
    ibuprofen caused bile in the stomach and esophagus man?
    ibuprofen cand liver and kidneys damage

    • ANSWER:
      ibuprofen can cause stomach ulcers
      it can in some cause acid reflux

      If you are sensitive to ibuprofen and you have to take it then take something like zantac 75mg or omeprazole 10mg to protect your stomach daily -and talk to doctor .

  30. QUESTION:
    Had wisdom teeth removed about a week ago. I have had yellow skin on my cheeks that spreads down to my upper?
    chest area for the last couple days now. Is this a normal sign of bruising or is it possibly liver damage from ibuprofen + vicodin + penicillin (antibiotic)?

    • ANSWER:

  31. QUESTION:
    What's the best pain killer? ibuprofen?
    My lower back hurts and I have a head ache. I've heard that acetaminophen can cause liver damage if you have too much or are exposed for too long. And aspirin is bad if you have stomach ulcers or internal bleeding as it thins your blood. What about ibuprofen?

    • ANSWER:
      You would have to be a chronic user of acetaminophen for it to be a lot of damage...

      If you don't have ulcers or internal bleeding then I would use Advil. That is what works the best for me.

      If you want to do things naturally....try a hot bath and then a heating pad in bed.

  32. QUESTION:
    How bad am I hurting my body?
    I take about 8 advil each day, which is about 1600 mg of ibuprofen. How much damage am I doing to my body? Liver damage?

    • ANSWER:
      The over-the-counter maximum daily dose of ibuprofen is 1200 mg/day. Long term use of even the maximum amount is associated with certain health risks (such as GI bleeding and kidney damage). There are some disease states which require high doses of anti-inflammatory medications for treatment. If you are currently taking ibuprofen as directed by your doctor, you will probably be fine. If this is so, it is important that you see your doctor regularly so that he/she can monitor the effects of the drug on your body (i.e. blood tests to assess kidney function, etc). Your doctor may choose to prescribe a prophylactic dose of a proton pump inhibitor (Nexium, Prilosec, Protonix, Aciphex) or H2 antagonist (Zantac, Pepcid, Tagamet) to prevent an NSAID induced ulcer. If you have heartburn-like symptoms or notice that you bleed/bruise easily, feel exteremely fatigued, or have bloody or "black as coal" stools, see your doctor immediately.

      If, however, you are taking 1600 mg/day longterm and are not under a doctor's care, your risk of eventually having these side effects is high. It is important that you let your doctor know that you are needing to take this much. Whatever problem is causing you to need to take this amount of ibuprofen on a regular basis should be addressed by doctor.

  33. QUESTION:
    I have a question about taking Ibuprofen with Excedrin?
    I have sinus headaches quite a bit and am always combining 2 Excedrin with 4 Advil Cold & Sinus. I may take that entire combination once every day! And when I'm sick, I may take it twice a day! How bad would this combination affect my liver and/or stomach? And how long would it take to possibly damage the liver, kidneys, stomach and anything else? Any suggestions as to what to take or do besides this?

    • ANSWER:
      It sounds like you have a chronic condition that needs to be treated accurately - instead of treating the symptoms. You could have a nasal obstruction, or allergies, etc.

      There is no way to predict how much, to what extent, etc, the damage to be done by these things could be. You have (if I remember right 5 drugs [asperin, acetominophine, caffiene, pseudoephadrine, and ibuprofen) which means that you increase the chances that each one of those five drugs will interact with another one of those drugs. These interactions do not need to take place instantly. It could occur over time - each one of those drugs has what is called a "half life" (meaning the time if takes for half of the drug to be removed from your system. - not the time that it works mind you, the time it is in your body) This is how drugs build up in your system.

      The point that I am getting at, is that taking these medications regularly, could have detrimental effects, and should NOT be taken so consistantly without a medical consult.

      If you believe allergies may play a part, try googling "allergies" and "enviormental controls" you will get lots of info.

      Also, google "neti pots" - they sound weird, but its totally safe and generally good for chronic nasal conditions.

      Good Luck

      .

  34. QUESTION:
    I think my friend had overdosed on Ibuprofen....?
    I think my friend had overdosed on Ibuprofen due to a depression. She took 6 within six hrs ( or four in six hrs, not surely remember). Fortunately, she stopped taking them the same day once she finally put herself together. I thought that she might get her liver damage or even die from doing such a thing. However, her health seems to still be in a good condition ( this happens two months ago). Why is that she didn't get health problem or sorry to say, die from doing that ?

    • ANSWER:
      that's only 1200 mg so it wasn't an overdose.

  35. QUESTION:
    Is it possible to get addicted to Acetaminophen (Tylenol) and/or Ibuprofen (Advil)?
    Does anyone know the addictive properties of OTC pain medicines like Tylenol and Advil? I have seen many articles talking about how unsafe it is to take such medicines over the long term because it leads to liver damage. But is the situation the same for someone with no liver damage, who doesn't consume alcohol most days, and who only takes one dose (2 pills) of either Advil or Tylenol every day?

    • ANSWER:
      There are no addictive properties to either one, but lots of people take it when they really don't need to - "just in case".

      Normal doses shouldn't harm your liver or kidneys if you are healthy and excrete it at a normal rate.

  36. QUESTION:
    What EXACTLY would happen if you took 10 or 15 aspirin/ibuprofen?
    I know it would damage your liver and stuff, and of course i'm not going to do it, but like what would you feel like? What would happen to your brain? Etc

    • ANSWER:
      Ibuprofen overdose damages your internal organs like liver. While in some cases it has been reported that it has result in a permanent liver damage, in other cases where the victim was taking the dose for a long and continued period it has resulted in organ failure one by one.

      Some more side effects are unsteadiness, blurred vision, ringing in the ears, gastrointestinal, nausea plus vomiting, diarrhea, stomach pain, probable loss of blood in intestinal areas or stomach or both, headache, agitation, drowsiness, incoherence and confusion etc. Sometimes more serious symptoms are also noticed in some victims though very rare such as seizure, gastrointestinal bleeding, metabolic acidosis, respiratory depression, hyperkalaemia, tachycardia, atrial fibrillation, coma, hepatic dysfunction, renal failure, cyanosis, and cardiac arrest etc. Until and unless the victim is allergic to ibuprofen, there is a slim chance that the victim would die from Ibuprofen Overdose.

      Ibuprofen Overdose can cause stinking vomiting, profuse sweating, severe abdominal pain, and can land you straight in the mental hospital for attempted suicide, where you may be medicated with things like liquid carbon or charcoal. Charcoal has the ability to absorb the drug before it can enter the systemic circulation. Another form of treatment to fight Ibuprofen overdose is gastric lavage which is not very popular, but is considered if the intake is potentially life threatening. This treatment can be performed within 60 minutes of ingestion of Ibuprofen.

      Below 100 mg/kg toxic effects of Ibuprofen are less likely. But doses above 400 mg/kg are considered an overdose and can result into any of the above consequences. It is not possible to determine a precise dose that crosses the danger line as it varies from person to person depending upon his/her weight, age and medical record of the individual patient.

      in other words, you would die a slow and painful death

  37. QUESTION:
    Ibuprofen overdose question?
    I think my friend had overdosed on Ibuprofen due to a depression. She took 6 within six hrs ( or four in six hrs, not surely remember). Fortunately, she stopped taking them the same day once she finally put herself together. I thought that she might get her liver damage or even die from doing such a thing. However, her health seems to still be in a good condition ( this happens two months ago). Why is that she didn't get health problem or sorry to say, die from doing that ?

    • ANSWER:
      Ibuprofen can cause spontaneous hemorrhage (bleeding) if you take it in high dosages over 4 or 5 days. If a blood vessel ruptures in her esophagus, she might not be able to get to a hospital ER quickly enough to be saved. Fact is, it's tough to save her, even if she DOES make it to a hospital. But the dose you described, while high, isn't enough to kill her, provided she only did it that one time. If she is depressed and taking large doses of medicines, she might be expressing suicidal ideations, and probably needs some medical intervention. Antidepressant drugs + psychotherapy can really help her a lot. Encourage her to seek professional help.

  38. QUESTION:
    What are some signs or symptoms of kidney damage?
    I used to be addicted to narcotic painkillers, many of which contained acetaminophen or ibuprofen along with the narcotic. I was a drinker too. It's been about 3 years since I stopped. They always check my liver enzymes at the doctor. They were elevated, but came back down to normal shortly after I got clean. I don't think they ever checked my kidneys though. What would be some signs that I have any kidney damage?

    • ANSWER:
      Hypertension (High Blood Pressure). You should go see a nephrologist to have your blood tested to find out what your kidney function is.

      Unless you are in severe kidney failure, there isn't going to be much to know. There are no skin rashes or things like that.

      I had a kidney transplant last year in July.

      Toward the end stages of kidney failure you will be tired all of the time, sleeping during the afternoon, your urine will be just about clear comming out, leg cramps, edima, swelleing of the angkles and feet (Water Retention) and so much more.

      Go see a nephrologist to confirm either way this is the best way to find out. You can contact me by clicking on my profile if you would like to ask more questions.

  39. QUESTION:
    Can I take 200mg ibuprofen daily for arthritis pain. It does not upset my stomach because I take prevacid?
    I also take crestor. Is there a question of liver damage??

    • ANSWER:
      If your already taking something for acid in your stomach DO NOT TAKE IBUPROFEN! Its really bad for your stomach and will only make your problem worse. I have arthiritis and I'm allergic to Ibuprofen which we all know is better for arthritis... I take tylenol and I only take it when its unbearable. I would ask your doctor tho what he thinks you should take.

  40. QUESTION:
    if some one is taking a lot of paracetamol and ibuprofen at night say 10 of each?
    and is on lithium and antidepressants how long would it take before liver damage could occur

    • ANSWER:
      well for a start taking too many paracetamol can prove very lethal indeed. but combining it with ibuprofen whilst on lithium and anti depressants is asking for certain trouble, i would say irreparable damage could happen to your body at any time.

  41. QUESTION:
    How many asprin/ibuprofen does it take to OD and pass out?
    I already know it damages your liver, but I need ot know this for a research project for school!

    • ANSWER:
      it depends on the weight of the person, the dose of the pills and the persons tolerance. There is no set number of pills. Just like drinking....what makes one person drunk, wont for everyone. Sorry

  42. QUESTION:
    Can too much Tylenol cause any serious damage?
    I've been alternating between Tylenol extra strength and Ibuprofen 800mg for about 3 months. I take at least two Tylenol every day. And 1 ibpuprofen 800mg before I go to bed every other night. I'm only 16. If I keep this up, would it eventually damage something? Like my liver?

    I'm not taking all of this just for the hell of it. I suffer from daily migraines. I was just recently put on topamax for the headaches...

    • ANSWER:
      Yes, Tylenol is deadly to the liver. Your liver can recover but you need to stop taking that stuff. Tylenol is liver toxic and it hasn't even been shown to definitively do anything at all for pain. But the amount of ibuprofen you are taking is also too much for a long term. Short term, no problem. But long term that much ibuprofen will damage the kidneys. You are taking a very poisonous cocktail.

  43. QUESTION:
    What is best to take for menstrual cramps?
    i get them really bad, i take tylenol, but i take tylenol for everything, and it can do sever liver damage! midol doesn't work that great. and ibuprofen is OK.

    • ANSWER:
      Take 800mg of Ibuprofen, its a cure all.

  44. QUESTION:
    did i take too much ibuprofen?
    i read about liver damage and im a paranoid person so i get freaked out easily. im 15 i pulled a muscle and the doctor gave a prescription for 600mg ibuprofen. I took it 3 times a day for 3 weeks then 1 time a day for a couple more days. is it harmful i hope not someone please tell me?

    • ANSWER:
      really, if you only take it while you have the pain then its fine. it just means like if you overdose what the doc prescribes then you can get into trouble. also if you take it long term it can give you problems but for a pulled muscle you should be fine once it heals stop taking the ibuprofen

  45. QUESTION:
    What is the most effective medication for menstrual cramps?
    I have had severe menstrual cramps for the last 10 years. They interfere with my life in general! In college the nurse first recommended that I take some ibuprofen 2 days before my period but the cramps were still bad. Then she put me on the pill which solved all my problems!! I have used the pill for two years with marvelous results. But the reality is I am not sexually active. I am unnecessarily manipulating the hormones of my body, which might interfere with my fertility in the future if I am blest to meet someone I want to have kids with. This spring I decided to junk the pill. Now I have to take more than the recommended dose of ibuprofen in order to just be able to get out of the bed for the first two days of my period. I don’t want to have liver damage!!! Does anyone know any other non-toxic medication that would end my monnightmare? Please let it be legal..I tried codeine and it worked great but my source got arrested!

    • ANSWER:
      Go see your gyn...maybe you have PMDD, there are prescription meds available. Also, talk with your gyn about your concerns about taking the pill. The pill has been available for over 50 years now, and doesn't seem to adversely affect fertility in most women. There are also the new, low dose pills available.

  46. QUESTION:
    I've just started going to an Orthopedic Surgeon for help with arthritic knees?
    She prescribed 400 mg. Ibuprofen a day and exercise along with a cortizone shot in the affected area. I've always heard NSAIDS taken regularly can cause liver damage and that cortizone shots can actually cause deterioration of joints, so I'm leary of starting this. I would like to hear from others who have this dilemma when it comes to treatment of osteoarthritis.

    • ANSWER:
      I have been seeing Orthopedic Surgeons for over 24 years now dealing with my knees. I highly doubt that the amount of Ibuprofen that she told you to take will hurt you. I have been on stuff that is A LOT stronger than that for quite a while now to manage the pain and I have no ill effects. As for the Cortisone shots they are wonderful when they work. When I was first diagnosed they worked wonders on my knee (not so much anymore but then again my case is pretty advanced), and they do not cause deterioration of joints any more than the arthritis is going to destroy them over time. There are other injections that might be more effective, Synivic , I have heard that if you are in the early stages they can provide up to 6 months of pain relief. My case was to advanced and they gave me no pain relief.
      If i where you and the cortisone worked for you then go for it.

  47. QUESTION:
    Am I taking too much Ibuprofen?
    I take 800mgs of ibuprofen every night so i can sleep cuz I have a lot of aches and pains that keep me awake otherwise. I am staying with my older sister and she freaked when she found out. She says I am taking too much and it's going to damage my liver and kidneys. Is this true? I am taking like generic Ibuprofen or Advil.
    It actually hasn't stopped working effectively even though I take it every night.

    • ANSWER:
      800mg of ibuprofen won't kill you. It is very hard on your stomach, so make sure you take it with food.

      It's not a good idea to take ibuprofen on a long term basis. You should be taking it only when you really need it. If you are in that much pain every night, you should talk to your doctor about trying to find and treat the underlying cause of the pain. It's quite possible that you have developed a dependency on ibuprofen, which means that you get pain anytime you stop taking it. In that case, it would be best to slowly wean yourself off of it.

  48. QUESTION:
    Could my taking too many painkillers have damaged my kidneys or liver?
    Okay, I know this is stupid and I don't want any lectures on this but I struggle with depression and stuff, and a few months ago I'd do anything just to get to sleep- including taking around 6-8 caplets of paracetamol or ibuprofen a night, plus some during the day because I got headaches.
    I can't remember how long it went on for, but I was never addicted and I don't do it anymore.
    Is there a chance it could have damaged my organs or anything?

    • ANSWER:
      You would have to take lots more then that and for a longer time, for the most part your body will heal itself. don't worry about any type of damage just be careful taking these for any length of time and if you do your best bet then is to get a blood test to check your levels for your kidneys and liver

  49. QUESTION:
    Does glucosamine help alleviate back pain caused by osteoarthritis?
    Most pain relief creams, etc. target the muscles, rather than the nerves that are affected by osteoarthritis. I have heard that glucosamine may be helpful in treating arthritis. I am not looking for a cure, just pain relief. I am currently taking high doses of Ibuprofen, which can cause liver damage. I would rather take something that targets the source of the problem. Has anyone taken glucosamine and had positive results for back pain relief?

    • ANSWER:
      Yes with chondrontin mixed with it, it will help arthritis pain and is alot more healthy than ibuprofen. You might want to get off of the ibuprofen for a while as it alone does not have long lasting results. Aleve has naproxin in it and very helpful.
      It concerns me that you say osteoarthritis, but you nerve pain relief?? OA usually causes severe joint pain. So if you are experiencing nerve pain as well you should see you doctor, because you may have ruptured or herniated a disc.

  50. QUESTION:
    Took alot of ibuprofen, should I get a checkup?
    Back in the years 2002-2004 I had a case of osteomiolitis (aka bone staph infection) in my left humerus. I've had Juvenile Rheumatoid Arthritis since 6th grade (or at least that's what the doc's thought) which traveled around my body frequently. So my parents and I assumed that's why my left arm hurt so much. But this pain was different, and a bit too late we found out it was staph. But that's just a quick history to lead up to my question: When my arm was hurting 24-7, I was taking sometimes 12 Ibuprofen every 1-2 hours for months at a time. I read somewhere that you should consult a doctor if you take 10 ibuprofen in one day! I've never had any symptoms of kidney or liver damage, and I've had numerous bloodtests during all the staph business and there's never been anything said about it. The only thing is I'd go through a bottle in 2 weeks (those 500 count bottles) because I couldn't sleep for more than an hour without having to get up and take something. Please serious answers only! Thanks
    Yes, serious answers are all I want. Like I said, there's been no concern from doctors in the past, but I don't know if someone on here may be an MD or had similar experiences. And thanks!

    • ANSWER:
      That is a lot of ibuprofen. A lot more than you should have and you're likely to be doing excessive damage. You need to tell your doctor truthfully. They wont judge you, but they need to know. Your doctor can test your kidneys and liver. They can also give you something stronger for your pain.

      EDIT- I partly agree with Jeffery. Don't take more than is recommended on the packet. You're already dealing with conditions that are debilitating, you don't want anymore. Today my GP prescribed me Ibuprofen 800mg slow release and Prednisone (20mgs). I take the Ibuprofen once daily at dinner time and it releases slowly. You only need to take it once a day and it's a higher dosage than over the counter stuff. If your pain isn't being resolved by Ibuprofen then you might need something stronger. I tried Naproxen, but it didn't work as well (mainly my new GP thinks I was given a too low a dose).

      It sounds like you need to speak to a rheumatologist. Please don't take more than the recommended dose of Ibuprofen. Not only are you potentially doing damage you are also risking becoming addicted to them. I know that sounds stupid, but you can definitely become dependent on medication like this and I would question whether this hasn't already happened.

      ....